Structure of PDB 4rhm Chain A Binding Site BS01

Receptor Information
>4rhm Chain A (length=308) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHMFSKFLMNVKGVTPRGSDWANRLGPVALFGYGAGMPRRAPLLDFFLQS
PRDCDHYAELTIHDKGPIECPPETVMFMPVLNCGQMLDEAAGTETPTSDE
WYLGSLEASTELLEKGYVPVSVGGDGSATLSMVEAYKRLFPSDDIVIVHF
DAHPDVSDPRSPLRVLLDKGLLKGVVSVGNRQVSSEDRKVRKLHKMFYMD
MHAIYSKGLFCIRDIRNDYPVFISIDADVLDPAFAPAVDSPVAGGLSTRD
LLHIMNGIRGPKVVGIDVYGYNPDLDVYRKDNVGLTAIALSKIIKEGILK
AYSISTHT
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4rhm Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4rhm Crystal Structure of an Arginase-like Protein from Trypanosoma brucei That Evolved without a Binuclear Manganese Cluster.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		D149 H151 D224 D226
Binding residue
(residue number reindexed from 1)		D151 H153 D226 D228
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.3.1: arginase.
Gene Ontology
Molecular Function
GO:0004053 arginase activity
GO:0008783 agmatinase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006525 arginine metabolic process
GO:0033389 putrescine biosynthetic process from arginine, using agmatinase

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4rhm, PDBe:4rhm, PDBj:4rhm
PDBsum4rhm
PubMed25536859
UniProtQ581Y0

[Back to BioLiP]