Structure of PDB 4rhg Chain A Binding Site BS01

Receptor Information
>4rhg Chain A (length=282) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRY
KDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCA
QFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS
EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPEHGVPDDSSDFLEFVN
YVRSLRVDSEPVLVHSSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRK
MRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4rhg Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Resolution1.581 Å
Binding residue
(original residue number in PDB)		D672 Y676 D678 E811 H812 S842 S843 A844 I846 G847 R848 Q886
Binding residue
(residue number reindexed from 1)		D46 Y50 D52 E185 H186 S216 S217 A218 I220 G221 R222 Q260
Enzymatic activity
Catalytic site (original residue number in PDB) E811 S842 R848 T849 Q886
Catalytic site (residue number reindexed from 1) E185 S216 R222 T223 Q260
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4rhg, PDBe:4rhg, PDBj:4rhg
PDBsum4rhg
PubMed25728925
UniProtP26045|PTN3_HUMAN Tyrosine-protein phosphatase non-receptor type 3 (Gene Name=PTPN3)

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