Structure of PDB 4rh5 Chain A Binding Site BS01

Receptor Information
>4rh5 Chain A (length=280) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYK
DVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ
FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSE
DCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPAHGVPDDSSDFLEFVNY
VRSLRVDSEPVLVHSSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKM
RDQRAMMVQTSSQYKFVCEAILRVYEEGLV
Ligand information
Receptor-Ligand Complex Structure
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PDB4rh5 Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		D672 Y676 D678 H812 S842 S843 A844 I846 G847 R848 Q886
Binding residue
(residue number reindexed from 1)		D45 Y49 D51 H185 S215 S216 A217 I219 G220 R221 Q259
Enzymatic activity
Catalytic site (original residue number in PDB) A811 S842 R848 T849 Q886
Catalytic site (residue number reindexed from 1) A184 S215 R221 T222 Q259
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4rh5, PDBe:4rh5, PDBj:4rh5
PDBsum4rh5
PubMed25728925
UniProtP26045|PTN3_HUMAN Tyrosine-protein phosphatase non-receptor type 3 (Gene Name=PTPN3)

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