Structure of PDB 4rdx Chain A Binding Site BS01

Receptor Information
>4rdx Chain A (length=409) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TARAVRGTKDLFGKELRMHQRIVATARKVLEAAGALELVTPIFEETQVFE
KEMFTFQDRGGRSLTLRPEGTAAMVRAYLEHGMKVWPQPVRLWMAGPMFR
AERPQKGRYRQFHQVNYEALGSENPILDAEAVVLLYECLKELGLRRLKVK
LSSVGDPEDRARYNAYLREVLSPHREALSEDSKERLELNPMRILDSKSER
DQALLKELGVRPMLDFLGEEARAHLKEVERHLERLSVPYELEPALVRGLD
YYVRTAFEVHHEEIGAQSALGGGGRYDGLSELLGGPRVPGVGFAFGVERV
ALALEAEGFGLPEEKGPDLYLIPLTEEAVAEAFYLAEALRPRLRAEYALA
PRKPAKGLEEALKRGAAFAGFLGEDELRAGEVTLKRLATGEQVRLSREEV
PGYLLQALG
Ligand information
>4rdx Chain C (length=77) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggugagcguagcucagcugguuagagcaccggacugugguccgggggucg
uggguucaagucccaucgcucacccca
<<<<<<<<..<<<<.........>>>>.<<<<<......>>>>>.....<
<<<<.......>>>>>>>>>>>>>...
Receptor-Ligand Complex Structure
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PDB4rdx Structural basis for recognition of G-1-containing tRNA by histidyl-tRNA synthetase
Resolution2.55 Å
Binding residue
(original residue number in PDB)		R7 M65 P80 E114 R115 Q117 K118 R120 R122 D193 R197 R204 K209 G260 A278 L336 P366 L370 L374 K375 F383 G385 D387 E388 K397 L399 Q404
Binding residue
(residue number reindexed from 1)		R6 M53 P68 E102 R103 Q105 K106 R108 R110 D181 R185 R192 K197 G248 A266 L324 P354 L358 L362 K363 F371 G373 D375 E376 K385 L387 Q392
Enzymatic activity
Enzyme Commision number 6.1.1.21: histidine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004821 histidine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006427 histidyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4rdx, PDBe:4rdx, PDBj:4rdx
PDBsum4rdx
PubMed25722375
UniProtP62374|SYH_THET2 Histidine--tRNA ligase (Gene Name=hisS)

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