Structure of PDB 4rcp Chain A Binding Site BS01
Receptor Information
>4rcp Chain A (length=223) Species:
9606
(Homo sapiens) [
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CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKY
GLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNS
LMKKITLLKYFRNYMSEHLLKAGANITPREGLPYLRTWFRTRSAIILHLS
NGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKEL
ASRLRYARTMVDKLLSSRSASNR
Ligand information
>4rcp Chain B (length=3) [
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HST
Receptor-Ligand Complex Structure
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PDB
4rcp
A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
Resolution
1.6 Å
Binding residue
(original residue number in PDB)
K413 W414 D416 Y417 Y421 Y481 F482 Y485 L490 L491 H538 K540
Binding residue
(residue number reindexed from 1)
K42 W43 D45 Y46 Y50 Y110 F111 Y114 L119 L120 H162 K164
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:4rcp
,
PDBe:4rcp
,
PDBj:4rcp
PDBsum
4rcp
PubMed
25347203
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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