Structure of PDB 4r8a Chain A Binding Site BS01

Receptor Information
>4r8a Chain A (length=538) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPEPFYYLHNFRAVLAWIGERYADLLDDQERAFIAAFAELPEASQALLVR
MVMRKGTLFREGKLAYAEIGDTRAAVQPLLALGWVDAQPTLELAQLFGLL
KKDELSQLFRDHLGRANLRKDALLERLQPLFPEARRLAEWQADFAEPVYE
LRCMALCDRLRLMYFGNLWQDWSEFVLADLGIYRYESVEFSADSRGFRLR
ADVDAYLHLFDCRQRFDLGEPLEELLAGLPGEPYANPWLEGRRVKLLFQF
AQHCEKQRDFDLAQRLYRQSSHPGARLRAIRSLERGERFAEAHALAREAS
CAPESDAERQGLARLLPRLQGKLGLPRQARAAAPEIDRLDLCLAFPSEPC
SVEWAVREHLEEPGCAVHYVENGLINSLFGLLCWEAIFAAIPGAFFHPFH
SAPADLHSADFRQRRAALFEACLGRLEDGSYRDAIRCRYRDKFGLQSPFV
YWELLGEELLEQALDCLPAAHLRAWFERLLEDIPGNRAGLPDLIQFWPAQ
RRYRMVEVKGPGDRLQDNQLRWLQFCREREMPVAVCYV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4r8a Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1
Resolution3.2 Å
Binding residue
(original residue number in PDB)		G181 N182 L183 Q185 Y221 F225 W253 R257 K260 K337 E368 E386 N387 H412 F414 H415 S416 A419 H422 A503 G504 D507 G527 D528 Q531
Binding residue
(residue number reindexed from 1)		G166 N167 L168 Q170 Y206 F210 W238 R242 K245 K322 E353 E371 N372 H397 F399 H400 S401 A404 H407 A488 G489 D492 G512 D513 Q516
Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004528 phosphodiesterase I activity
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070336 flap-structured DNA binding
Biological Process
GO:0006281 DNA repair
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4r8a, PDBe:4r8a, PDBj:4r8a
PDBsum4r8a
PubMed25319828
UniProtQ9I2N0|FAN1_PSEAE Fanconi-associated nuclease 1 homolog (Gene Name=fan1)

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