Structure of PDB 4r3v Chain A Binding Site BS01

Receptor Information
>4r3v Chain A (length=179) Species: 203275 (Tannerella forsythia 92A2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QRLYDNGPLTGDNNYVLQGSKWNKTTLKYYIYNSSSHLTTTERENAIRSA
FALWSDKSTLSFIQVYNPNQADIKIKWEKGNHGDGYPFDGNTGILAHAFY
PPPAGGNYAGHLHFDGDENWSINGSGIDLITVAAHAIGHLLGIEHSNVSS
ALMYPYYTGIKRQLDNDDCLAVWDLYGYP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4r3v Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4r3v A novel mechanism of latency in matrix metalloproteinases.
Resolution2.01 Å
Binding residue
(original residue number in PDB)		D25 H155 H159 H165
Binding residue
(residue number reindexed from 1)		D5 H135 H139 H145
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H155 A156 H159 H165
Catalytic site (residue number reindexed from 1) H135 A136 H139 H145
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4r3v, PDBe:4r3v, PDBj:4r3v
PDBsum4r3v
PubMed25555916
UniProtD0EM77|KLY_TANFA Karilysin (Gene Name=kly)

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