Structure of PDB 4r3p Chain A Binding Site BS01

Receptor Information
>4r3p Chain A (length=310) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIK
ELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPF
GCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV
KTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQS
DVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM
IMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPDEDMD
DVVDADEYLI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4r3p Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Resolution2.905 Å
Binding residue
(original residue number in PDB)		D837 R841 G874 K875 V876 P877 R889 A920
Binding residue
(residue number reindexed from 1)		D142 R146 G179 K180 V181 P182 R194 A225
Enzymatic activity
Catalytic site (original residue number in PDB) D837 A839 R841 N842 D855
Catalytic site (residue number reindexed from 1) D142 A144 R146 N147 D160
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4r3p, PDBe:4r3p, PDBj:4r3p
PDBsum4r3p
PubMed26280531
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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