Structure of PDB 4qze Chain A Binding Site BS01

Receptor Information

>4qze Chain A (length=335) Species: 10090 (Mus musculus)

KKISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRASSV
LKSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDERYK
SFKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYYE
DLVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDFL
ITSPEATEDEEQQLLHKVTDFWKQQGLLLYCDILQKCFLILKLDHGRVHG
KGWKAIRVDLVMCPYDRRAFALLGWTGSRQFERDLRRYATHERKMMLDNH
ALYDRTKRVFLEAESEEEIFAHLGLDYIEPWERNA

Ligand information

>4qze Chain D (length=6)

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 4qze Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair.
• Resolution: 2.25 Å
• Binding residue (original residue number in PDB): G186 S187 A190 P215 C216 G218 K220 V221
• Binding residue (residue number reindexed from 1): G39 S40 A43 P68 C69 G71 K73 V74

Enzymatic activity

• Catalytic site (original residue number in PDB): D343 D345 D434
• Catalytic site (residue number reindexed from 1): D196 D198 D259
• Enzyme Commision number: 2.7.7.31: DNA nucleotidylexotransferase.
  3.1.11.-

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0034061 DNA polymerase activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:4qze, PDBe:4qze, PDBj:4qze
• PDBsum: 4qze
• PubMed: 25762590
• UniProt: P09838|TDT_MOUSE DNA nucleotidylexotransferase (Gene Name=Dntt)