Structure of PDB 4qzc Chain A Binding Site BS01

Receptor Information
>4qzc Chain A (length=351) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVKKISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRAS
SVLKSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDER
YKSFKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLY
YEDLVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVD
FLITSPEATEDEEQQLLHKVTDFWKQQGLLLYCDILESTFEKFDLDHFQK
CALILKLDHGRVHQEGKGWKAIRVDLVMCPYDRRAFALLGWTGSRQFERD
LRRYATHERKMMLDNHALYDRTKRVFLEAESEEEIFAHLGLDYIEPWERN
A
Ligand information
Receptor-Ligand Complex Structure
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PDB4qzc Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		G186 S187 A190 C216 G218 K220 V221
Binding residue
(residue number reindexed from 1)		G41 S42 A45 C71 G73 K75 V76
Enzymatic activity
Catalytic site (original residue number in PDB) D343 D345 D434
Catalytic site (residue number reindexed from 1) D198 D200 D275
Enzyme Commision number 2.7.7.31: DNA nucleotidylexotransferase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4qzc, PDBe:4qzc, PDBj:4qzc
PDBsum4qzc
PubMed25762590
UniProtP09838|TDT_MOUSE DNA nucleotidylexotransferase (Gene Name=Dntt)

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