Structure of PDB 4qz8 Chain A Binding Site BS01

Receptor Information
>4qz8 Chain A (length=346) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRASSV
LKSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDERYK
SFKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYYE
DLVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDFL
ITSPEATEDEEQQLLHKVTDFWKQQGLLLYCDILESTFVALDHFQKCFLI
LKLDHGRVHSGKGWKAIRVDLVMCPYDRRAFALLGWTGSRQFERDLRRYA
THERKMMLDNHALYDRTKRVFLEAESEEEIFAHLGLDYIEPWERNA
Ligand information
Receptor-Ligand Complex Structure
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PDB4qz8 Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		G186 S187 A190 C216 G218 K220 V221
Binding residue
(residue number reindexed from 1)		G39 S40 A43 C69 G71 K73 V74
Enzymatic activity
Catalytic site (original residue number in PDB) D343 D345 D434
Catalytic site (residue number reindexed from 1) D196 D198 D270
Enzyme Commision number 2.7.7.31: DNA nucleotidylexotransferase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4qz8, PDBe:4qz8, PDBj:4qz8
PDBsum4qz8
PubMed25762590
UniProtP09838|TDT_MOUSE DNA nucleotidylexotransferase (Gene Name=Dntt)

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