Structure of PDB 4qx8 Chain A Binding Site BS01
Receptor Information
>4qx8 Chain A (length=329) Species:
10090
(Mus musculus) [
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RTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLG
IKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEE
EREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTEST
NAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIP
PTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHA
VYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWY
VLERYVYCITNRSHLTKDFQKESLSMDME
Ligand information
>4qx8 Chain E (length=11) Species:
10090
(Mus musculus) [
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APATGGVKKPH
Receptor-Ligand Complex Structure
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PDB
4qx8
A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.
Resolution
1.65 Å
Binding residue
(original residue number in PDB)
M111 Q116 I144 S145 N186 A187 I188 Y199 L201 T209 D214 F215 V220 N298 V320 K323 F324 R325
Binding residue
(residue number reindexed from 1)
M76 Q81 I109 S110 N151 A152 I153 Y164 L166 T174 D179 F180 V185 N263 V285 K288 F289 R290
Enzymatic activity
Enzyme Commision number
1.14.11.27
: [histone H3]-dimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:4qx8
,
PDBe:4qx8
,
PDBj:4qx8
PDBsum
4qx8
PubMed
25128496
UniProt
P59997
|KDM2A_MOUSE Lysine-specific demethylase 2A (Gene Name=Kdm2a)
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