Structure of PDB 4qwn Chain A Binding Site BS01
Receptor Information
>4qwn Chain A (length=329) Species:
10090
(Mus musculus) [
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RTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLG
IKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEE
EREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTEST
NAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIP
PTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHA
VYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWY
VLERYVYCITNRSHLTKDFQKESLSMDME
Ligand information
>4qwn Chain E (length=10) Species:
10090
(Mus musculus) [
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APATGGVKKP
Receptor-Ligand Complex Structure
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PDB
4qwn
A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
M111 G118 I144 S145 N186 A187 I188 Y199 T209 F215 Y222 N298 K323 F324
Binding residue
(residue number reindexed from 1)
M76 G83 I109 S110 N151 A152 I153 Y164 T174 F180 Y187 N263 K288 F289
Enzymatic activity
Enzyme Commision number
1.14.11.27
: [histone H3]-dimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:4qwn
,
PDBe:4qwn
,
PDBj:4qwn
PDBsum
4qwn
PubMed
25128496
UniProt
P59997
|KDM2A_MOUSE Lysine-specific demethylase 2A (Gene Name=Kdm2a)
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