Structure of PDB 4qqy Chain A Binding Site BS01

Receptor Information
>4qqy Chain A (length=896) Species: 269800 (Thermobifida fusca YX) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPLDLRFWAKERGLRGKTYPLVCHSLDAAAAALVLWNEYLSPGLRDTIAS
SMETDEEHAGHCIAFWAGLHDIGKLTREFQQQIAIDLSAYPGEELSGEQR
SHAAATGKWLPFALPSLGYPNGGLVTGLVAQMLGGHHGTFHPHPSFQSRN
PLAEFGFSSPHWEKQRHALLHAVFDATGRPTPPDMLDGPTASVVCGLVIL
ADWLVSQEDFLLERLTSLPADGSASALRAHFETSLRRIPSLLDAAGLRPI
TVPPATFTESFPHLSKPNGLQASLAKHLPCLCTGPGLVLITAPMGEGKTE
AAYHVADLLGKATGRPGRFLALPTMATADQMHTRLKEYARYRVEPRSSTL
ALLHSMAWLNPDYAPAGHRDPFAATDWLMGRKRGLLAPWAVGTIDQALMA
VLRAKHNALRLFGLAGKVVVVDEAHAVDPYMQVLLEQLLRWLGTLDVPVV
LLSATLHHSIANSLVKAYLEGARGRRWNRSEPQPVSEVSYPGWLHVDARI
GKVTRSSDVDPLPIATTPRKPLEVRLVDVPVKEGALNRSTVLAKELTPLV
KQGGCAAIICTTVAEAQGVYDLLSQWFATAPDLYLLHSRFPNRQRTEITA
TIVDLFGKEGAQSGRRPTAVLVATQVVEQSLDLDVDLMISDLAPVSLLLQ
RAGRCWRHEHLGIINRPQWAKQPELVVLTPEQNRAPWFPRSWTSVYPLAL
LQRTYTLLRRRNGAPVQIPEDVQQLVDDVYDDDSLAEDLEADMERMGEEL
AQRGLARNAVIPDPDDAEDNLNGLTEFSFHVLATRFGAGSVRVLCYYVDT
AGNRWLDPECTVEFPEQGTEGRFTMADCRDLVARTIPVRMGPWASQLTED
NHPPEAWRESFYLRDLVLIPQRVTDVLPTETGGREWLLDPCKGLIF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4qqy Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Resolution3.12 Å
Binding residue
(original residue number in PDB)
K23 D84 K87 H150 D215 W216 S219 E221 T337 M338 H371 S372 R410 T422 D424 M428 T590 T591 V592 S621 R628 T659 Q660 Q664 R729 S733 V734 R828 G832 S833 R884 F906
Binding residue
(residue number reindexed from 1)
K10 D71 K74 H137 D202 W203 S206 E208 T324 M325 H354 S355 R381 T393 D395 M399 T561 T562 V563 S588 R595 T624 Q625 Q629 R690 S694 V695 R785 G789 S790 R839 F861
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0051607 defense response to virus
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:4qqy, PDBe:4qqy, PDBj:4qqy
PDBsum4qqy
PubMed25132177
UniProtQ47PJ0

[Back to BioLiP]