Structure of PDB 4qpx Chain A Binding Site BS01

Receptor Information
>4qpx Chain A (length=495) Species: 11983 (Norwalk virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKGTYCGAPILGPGSAPKLSTKTKFWRSSTAPLPPGTYEPAYLGGKDPRV
KGGPSLQQVMRDQLKPFTEPRGKPPKPSVLEAAKKTIINVLEQTIDPPDK
WSFAQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLADQASKANLMFEE
GKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFGGLM
DELKTHCVTLPIRVGMNMNEDGPIIFERHSRYRYHYDADYSRWDSTQQRA
VLAAALEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFTISINEGLPSGVP
CTSQWNSIAHWLLTLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKL
DPEKLTAKLKEYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWF
GKLEQSSILRQMYWTRGPNHEDPSETMIPHSQRPIQLMSLLGEAALHGPA
FYSKISKLVIAELYVPRQEPMFRWMRFSDLSTWEGDRNLAPSFVN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4qpx Structure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymerase.
Resolution1.86 Å
Binding residue
(original residue number in PDB)		T116 R126 K166 D242 D247 S300 G301 S306 Y341 D343 D344 L391 R392 S410 R413 Q414 R419 Q435 Q439
Binding residue
(residue number reindexed from 1)		T113 R123 K163 D239 D244 S297 G298 S303 Y338 D340 D341 L388 R389 S407 R410 Q411 R416 Q432 Q436
Enzymatic activity
Enzyme Commision number 3.4.22.66: calicivirin.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4qpx, PDBe:4qpx, PDBj:4qpx
PDBsum4qpx
PubMed25478829
UniProtQ70ET3

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