Structure of PDB 4qil Chain A Binding Site BS01
Receptor Information
>4qil Chain A (length=299) Species:
9606
(Homo sapiens) [
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SGVEDTKHYEEAKKCVEELALYLKQSVLSRPMQRKLVTLVHCQLVEEEGR
IRAMRAARSLGERTVTELILQHQNPQQLSSNLWAAVRARGCQFLGPAMQE
EALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYR
ASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPD
QWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLN
RLRPHLELLANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSK
Ligand information
>4qil Chain C (length=16) [
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ucccuucugugaaggg
.<<<<<<...>>>>>>
Receptor-Ligand Complex Structure
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PDB
4qil
The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.
Resolution
2.9 Å
Binding residue
(original residue number in PDB)
W184 R188 F194 R219 K220 S238 K239 T240 Q247 Y250 R251 S253 E262 D263 S264 S265
Binding residue
(residue number reindexed from 1)
W83 R87 F93 R118 K119 S137 K138 T139 Q146 Y149 R150 S152 E161 D162 S163 S164
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
External links
PDB
RCSB:4qil
,
PDBe:4qil
,
PDBj:4qil
PDBsum
4qil
PubMed
25026078
UniProt
Q5TC82
|RC3H1_HUMAN Roquin-1 (Gene Name=RC3H1)
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