Structure of PDB 4qik Chain A Binding Site BS01
Receptor Information
>4qik Chain A (length=302) Species:
9606
(Homo sapiens) [
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GVEDTKHYEEAKKCVEELALYLKPLSSARGVGLNSTTQSVLSRPMQRKLV
TLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLSSNLWAAVR
ARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQAS
KTSIGHVVQLLYRASCFKSLMQLKEEFRTYEALRREHDSQIVQIAMEAGL
RIAPDQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGD
PANLNRLRPHLELLANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQ
NH
Ligand information
>4qik Chain C (length=18) [
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auguuuucuggaaaacgg
..................
Receptor-Ligand Complex Structure
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PDB
4qik
The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
S315 Q318 S319 D322 K323
Binding residue
(residue number reindexed from 1)
S219 Q222 S223 D226 K227
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
External links
PDB
RCSB:4qik
,
PDBe:4qik
,
PDBj:4qik
PDBsum
4qik
PubMed
25026078
UniProt
Q5TC82
|RC3H1_HUMAN Roquin-1 (Gene Name=RC3H1)
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