Structure of PDB 4qei Chain A Binding Site BS01

Receptor Information
>4qei Chain A (length=562) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVDRAKMGDTLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQ
HFIQEEQILEIDCTMLTPEPVLKTSGHVDKFADFMVKDVKNGERFRADHL
LKAHLQKLQQELADLFVNFNLMFKTFIGPGGNMPGYLRPETAQGIFLNFK
RLLEFNQGKLPFAAAQIGNSFRNEISPRSGLIRVREFTMAEIEHFVDPSE
KDHPKFQNVADLHLYLYSAKAQVSGQSARKMRLGDAVEQGVINNTVLGYF
IGRIYLYLTKVGISPDKLRFRQHMEDCWDAESKTSYGWIEIVGCADRSCY
DLSCHARATKVPLVAEKPLKEPKTVNVVQFEPSKGAIGKAYKKDAKLVME
YLAICDECYITEMEMLLNEKGEFTIETQLTKDMINVKRFQKTLYVEEVVP
NVIEPSFGLGRIMYTVFEHTFHVREGDEQRTFFSFPAVVAPFKCSVLPLS
QNQEFMPFVKELSEALTRHGVSHKVDDSSGSIGRRYARTDEIGVAFGVTI
DFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQDLANGNITWADVEAR
YPLFEGQETGKK
Ligand information
>4qei Chain C (length=69) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgccgcugguguagugguaucaugcaagauucccauucuugcgacccgg
guucgauucccgggcggcg
.<<<<<<..<<<.........>>><<<<<<.......>>>>>>...<<<<
<.......>>>>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4qei Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA Synthetase (hGlyRS) during Catalysis
Resolution2.875 Å
Binding residue
(original residue number in PDB)		D72 R76 Q82 G88 G89 S91 I280 D545 Q547 R548 L567 S568 N570 S596 S597 S599 G601 R602 Y604 A605 R606 E609 T617 D619 F620 T631 R633 M638 Q640 F672 Q675
Binding residue
(residue number reindexed from 1)		D9 R13 Q19 G25 G26 S28 I175 D427 Q429 R430 L449 S450 N452 S478 S479 S481 G483 R484 Y486 A487 R488 E491 T499 D501 F502 T513 R515 M520 Q522 F554 Q557
Binding affinityPDBbind-CN: Kd=15.84uM
Enzymatic activity
Enzyme Commision number 2.7.7.-
6.1.1.14: glycine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004820 glycine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006426 glycyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qei, PDBe:4qei, PDBj:4qei
PDBsum4qei
PubMed26797133
UniProtP41250|GARS_HUMAN Glycine--tRNA ligase (Gene Name=GARS1)

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