Structure of PDB 4q8h Chain A Binding Site BS01

Receptor Information
>4q8h Chain A (length=627) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PETSDIQTYTSINKYEVPPAYSRLPLTSGRFGTDNFDFTPFNNTEYSGLD
PDVDNHYTNAIIQLYRFIPEMFNFVVGCLKDENFETTLLTDLGYLFDMME
RSHGKICSSSNFQASLKSLTDKRQEEYLESLCIRESIEDFNSSESIKRNM
PQKFNRFLLSQLIKEEAQTVNHNITLNQCFGLETEIRTECSCDHYDTTVK
LLPSLSISGINKTGQNILPYIEYAMKNVTQKNSICPTCGKTETITQECTV
KNLPSVLSLELSLLDTEFSNIRSSKNWLTSEFYGSIIKNKAVLRSTASEL
KGTSHIFKYELNGYVAKITDNNNETRLVTYVKKYNPKENCFKWLMFNDYL
VVEITEEEALKMTYPWKTPEIIIYCDAEELRKPFFSVDTYSINYDILFRD
YFANGIRDTARREYKLLTHDEAPKSGTLVAIDAEFVSLQSELCEIDHIRP
KRTALARISIIRGEEGELYGVPFVDDYVVNTNHIEDYLTRYSGILPGDLD
PEKSTKRLVRRNVVYRKVWLLMQLGCVFVGHGLNNDFKHININVPRNQIR
DTAIYFLQGKRYLSLRYLAYVLLGMNIQEGNHDSIEDAHTALILYKKYLH
LKEKAIFEKVLNSVYEEGRAHNFKVPE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4q8h Chain A Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4q8h The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D910 E912 D1071
Binding residue
(residue number reindexed from 1)		D432 E434 D587
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.13.4: poly(A)-specific ribonuclease.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:4q8h, PDBe:4q8h, PDBj:4q8h
PDBsum4q8h
PubMed24880344
UniProtP53010|PAN2_YEAST PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (Gene Name=PAN2)

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