Structure of PDB 4q8f Chain A Binding Site BS01

Receptor Information
>4q8f Chain A (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPKTALATREQVQWWLLQLAQELEERLTKDR
NDNDRVATQLVVSIRVQGDKLSSLRRCCALTRYDAHKMSHDAFTVIKNCN
TSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4q8f Structural and mechanistic studies of polymerase eta bypass of phenanthriplatin DNA damage.
Resolution2.797 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 W64 K86 K293 P316 K317 G320 C321 S322 K323 N324 P326 R351
Binding residue
(residue number reindexed from 1)		Q38 Y39 W42 W64 K86 K288 P311 K312 G315 C316 S317 K318 N319 P321 R345
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4q8f, PDBe:4q8f, PDBj:4q8f
PDBsum4q8f
PubMed24927576
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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