Structure of PDB 4q5j Chain A Binding Site BS01

Receptor Information

>4q5j Chain A (length=298) Species: 3702 (Arabidopsis thaliana)

DLEVLFQGPHMAFEKPLRKLTFADLLQATNGFHNDSLIGSGGFGDVYKAI
LKDGSAVAIKKLIHVSDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLL
VYEFMKYGSLEDVLKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKS
SNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFR
CSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVF
DPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEIQA

Ligand information

>4q5j Chain E (length=15) Species: 3702 (Arabidopsis thaliana)

MEELQAAIQAAIAHC

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4q5j Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1.
• Resolution: 2.772 Å
• Binding residue (original residue number in PDB): K1101 K1105 L1128 V1135 D1139 D1140
• Binding residue (residue number reindexed from 1): K239 K243 L266 V273 D277 D278

Enzymatic activity

• Catalytic site (original residue number in PDB): D1009 K1011 S1013 N1014 D1027 M1037 T1049
• Catalytic site (residue number reindexed from 1): D147 K149 S151 N152 D165 M175 T187
• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.
  2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:4q5j, PDBe:4q5j, PDBj:4q5j
• PDBsum: 4q5j
• PubMed: 25331450
• UniProt: O22476|BRI1_ARATH Protein BRASSINOSTEROID INSENSITIVE 1 (Gene Name=BRI1)