Structure of PDB 4q13 Chain A Binding Site BS01
Receptor Information
>4q13 Chain A (length=226) Species:
9606
(Homo sapiens) [
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LALSLTADQMVSALLDAEPPILYSEYDPTRPSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSG
VYTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSN
KGMEHLYSMKCKNLYGLLLEMLDAHR
Ligand information
>4q13 Chain C (length=6) Species:
32630
(synthetic construct) [
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ILHRLL
Receptor-Ligand Complex Structure
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PDB
4q13
Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Resolution
2.24 Å
Binding residue
(original residue number in PDB)
I358 K362 L372 E542 M543
Binding residue
(residue number reindexed from 1)
I52 K56 L66 E220 M221
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:4q13
,
PDBe:4q13
,
PDBj:4q13
PDBsum
4q13
PubMed
26836308
UniProt
P03372
|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)
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