Structure of PDB 4pxm Chain A Binding Site BS01
Receptor Information
>4pxm Chain A (length=230) Species:
9606
(Homo sapiens) [
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ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSN
KGMEHLYSMKCKNVVPLYGLLLEMLDAHRL
Ligand information
>4pxm Chain C (length=6) Species:
9606
(Homo sapiens) [
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ILHRLL
Receptor-Ligand Complex Structure
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PDB
4pxm
Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
I358 K362 L372 V376 G538 E542
Binding residue
(residue number reindexed from 1)
I52 K56 L66 V70 G219 E223
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:4pxm
,
PDBe:4pxm
,
PDBj:4pxm
PDBsum
4pxm
PubMed
26836308
UniProt
P03372
|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)
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