Structure of PDB 4put Chain A Binding Site BS01

Receptor Information
>4put Chain A (length=692) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLSSNPLLQNFDFPPFDSVDAHHVRPGIRALLQQLEAELEQLEKAVEPSW
PKLVEPLEKIIDRLSVVWGMINHLKAVKDTPELRAAIEEVQPEKVKFQLR
LGQSKPIYNAFKAIRESPDWNSLSEARQRLVEAQIKEAVLSGIALEDDKR
EEFNKIEQELEKLSHKFSENVLDATKKFEKLITDKKEIEGLPPSALGLFA
QAAVSKGHETATADTGPWLITLDAPSYLPVMQHAKNRALREEVYRAYLSR
ASSGDLDNTAIIDQILKLRLEKAKLLGYRNYAEVSMATKMATVEKADELL
EKLRSASWDPAVQDIEDLKSFAKNQGAAEADSLTHWDITFWSERLRESKY
DINEEELRPYFSLPKVMDALFGLAKTLFGIDVVPADGVAPVWNSDVRFYC
VKDSSGNPTAYFYFDPYSRPSEKRDGAWMDEVFSRSRVMAQKGSSVRLPV
AQMVCNQTPPVGDKPSLMTFREVETVFHEFGHALQHMLTKEDEGLVAGIR
NIEWDAVELPSQFMENWCYHRDTLMSIAKHYQTGETLPENVYKKLLAART
FRAGSLSLRQLKFATVDLELHTKYMPGGAETIYEVDQRVSIKTQVIPPLP
EDRFLCSFSHIFAGGYAAGYYSYKWAEVLSADAFSAFEDAGLDDIKAVKE
TGQRFRNTILALGGGKAPLKVFVEFRGREPSPEPLLRHNGLL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4put Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4put Structure of the Arabidopsis thaliana TOP2 oligopeptidase.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		H483 H487 E513
Binding residue
(residue number reindexed from 1)		H478 H482 E508
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H483 E484 H487 E513 Y628
Catalytic site (residue number reindexed from 1) H478 E479 H482 E508 Y623
Enzyme Commision number 3.4.24.70: oligopeptidase A.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0048046 apoplast

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4put, PDBe:4put, PDBj:4put
PDBsum4put
PubMed24817709
UniProtQ949P2|COPDA_ARATH Probable cytosolic oligopeptidase A (Gene Name=CYOP)

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