Structure of PDB 4puq Chain A Binding Site BS01

Receptor Information
>4puq Chain A (length=256) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNGLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVI
PPYCAYLKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKM
MRNLLCVNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDS
TTVIFAGDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNN
LRIPAAYKHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLC
TLNVVL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4puq Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2DNA and Top2RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2).
Resolution1.6 Å
Binding residue
(original residue number in PDB)		H236 S239 T240 R241 D272 N274 R276 W307 L315 Y321 H359
Binding residue
(residue number reindexed from 1)		H122 S125 T126 R127 D158 N160 R162 W193 L201 Y207 H245
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:4puq, PDBe:4puq, PDBj:4puq
PDBsum4puq
PubMed24808172
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

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