Structure of PDB 4ppe Chain A Binding Site BS01

Receptor Information
>4ppe Chain A (length=66) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPSGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLKNANTCP
TCRKKINHKRYHPIYI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4ppe Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ppe RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		C136 C139 C163 C166
Binding residue
(residue number reindexed from 1)		C8 C11 C35 C38
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:4ppe, PDBe:4ppe, PDBj:4ppe
PDBsum4ppe
PubMed24714598
UniProtP78317|RNF4_HUMAN E3 ubiquitin-protein ligase RNF4 (Gene Name=RNF4)

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