Structure of PDB 4pp5 Chain A Binding Site BS01

Receptor Information
>4pp5 Chain A (length=214) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDMPVERILEAELAVEPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPL
DDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGA
IFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALRE
KVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGD
TPIDTFLMEMLEAP
Ligand information
Receptor-Ligand Complex Structure
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PDB4pp5 Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		V280 K284 L294 V298 R302 T449 E453
Binding residue
(residue number reindexed from 1)		V36 K40 L50 V54 R58 T205 E209
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4pp5, PDBe:4pp5, PDBj:4pp5
PDBsum4pp5
PubMed24801499
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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