Structure of PDB 4pof Chain A Binding Site BS01

Receptor Information
>4pof Chain A (length=255) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVDREEMIERFANFLREYTDEDGNPVYRGKITDLLTITPKRSVAIDWMHL
NSFDSELAHEVIENPEEGISAAEDAIQIVLREDFQREDVGKIHARFYNLP
ETLMVKDIGAEHINKLIQVEGIVTRVGEIKPFVSVAVFVCKDCGHEMIVP
QKPYESLEKVKKCEQCGSKNIELDVNKSSFVNFQSFRIQDRPETLKGGEM
PRFIDGILLDDIVDVALPGDRVIVTGILRVVLEKREKTPIFRKILEVNHI
EPVSK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4pof Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4pof A conserved MCM single-stranded DNA binding element is essential for replication initiation.
Resolution2.648 Å
Binding residue
(original residue number in PDB)		C139 C142 C162 C165
Binding residue
(residue number reindexed from 1)		C140 C143 C163 C166
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
Biological Process
GO:0032508 DNA duplex unwinding

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Molecular Function
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Biological Process
External links
PDB RCSB:4pof, PDBe:4pof, PDBj:4pof
PDBsum4pof
PubMed24692448
UniProtQ8U3I4

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