Structure of PDB 4po6 Chain A Binding Site BS01

Receptor Information
>4po6 Chain A (length=475) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFA
LFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRC
GPPGQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESL
GMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRL
RNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLA
QAEGEPCYIRDAGPPTHEVLVTGTGGIQWWPVEPLWAYFCDFRDITHVVL
KEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEV
APPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVA
QRSQAPDGMQSLRLRKFPIEQAFVLEGWGRSFPSVRELGAALQGCLLRAG
DDCFSLRRCCLPQPGETSNLIIMRG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4po6 Structural basis of IFN receptor recognition by TYK2
Resolution1.99 Å
Binding residue
(original residue number in PDB)		G140 Q142 L144 P146 F149 S476 T477 S478 H479 R482 I484 R503 K504 F505 P506 E517 W519 C536 L537 L538 R539
Binding residue
(residue number reindexed from 1)		G106 Q108 L110 P112 F115 S388 T389 S390 H391 R394 I396 R415 K416 F417 P418 E426 W428 C445 L446 L447 R448
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4po6, PDBe:4po6, PDBj:4po6
PDBsum4po6
PubMed
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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