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Receptor Information

>4ph7 Chain A (length=401) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

IDTDDIDEDDESGHNIILNIISQLRPGCDLTRITLPTFILEKKSMLERVT
NQLQFPEFLLQAHSEKDPLKRFLYVMKWYLAGWHIAPKAVKKPLNPVLGE
YFTAYWDLPNKQQAYYISEQTSHHPPECAYFYMIPESSIRVDGVVIPKSR
FLGNSSAAMMDGSTVLQFLDIKDGNGKPEKYVLTQPNVYVRGILFGKMRI
ELGDHMIIKSPNFQADIEFKTKGYVFGTYDAIEGTVKDYDGNAYYEISGK
WNDVMYLKDLKQPRSSPKVFLDTHKESPLRPKVRPLSEQGEYESRKLWKK
VTDALAVRNHPVATEEKFQIEDHQRQLAKKRIEDGVEFHPKLFRRSKPGE
DLDYCIYKNIPVDEDPEKQIRSILQIAPILPGQQFTDKFFIPAFEKIKSQ
K

Ligand ID

2Y5

InChI

InChI=1S/C47H84O16P2/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(49)61-39(37-59-40(48)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2)38-60-65(57,58)63-47-44(52)42(50)46(43(51)45(47)53)62-64(54,55)56/h11,13,17,19,22,24,28,30,39,42-47,50-53H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3,(H,57,58)(H2,54,55,56)/b13-11-,19-17-,24-22-,30-28-/t39-,42-,43+,44-,45-,46+,47+/m1/s1

InChIKey

ROKMWIUSHIHOGI-BWTMTLBLSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.9.2	CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OC1C(C(C(C(C1O)O)OP(=O)(O)O)O)O)OC(=O)CCCC=CCC=CCC=CCC=CCCCCC
ACDLabs 12.01	O=C(OCC(OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC)COP(=O)(O)OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1O)CCCCCCCCCCCCCCCCC
CACTVS 3.385	CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P](O)(=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](O[P](O)(O)=O)[C@@H](O)[C@H]1O)OC(=O)CCC\C=C/C/C=C\C\C=C/C\C=C/CCCCC
OpenEye OEToolkits 1.9.2	CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OC1[C@@H]([C@H](C([C@H]([C@H]1O)O)OP(=O)(O)O)O)O)OC(=O)CCCC=CCC=CCC=CCC=CCCCCC
CACTVS 3.385	CCCCCCCCCCCCCCCCCC(=O)OC[CH](CO[P](O)(=O)O[CH]1[CH](O)[CH](O)[CH](O[P](O)(O)=O)[CH](O)[CH]1O)OC(=O)CCCC=CCC=CCC=CCC=CCCCCC

Formula

C47 H84 O16 P2

Name

(2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate;
Phosphatidylinositol-4-phosphate;
PI4P

PDB chain

4ph7 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4ph7 INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate.
Resolution	2.55 Å
Binding residue (original residue number in PDB)	L64 T65 R66 L69 I73 M79 Q86 K125 K126 N129 H157 H158 S183 S190 A191 A192 Q219 V222 V224 I227 K351 E355 R359
Binding residue (residue number reindexed from 1)	L30 T31 R32 L35 I39 M45 Q52 K91 K92 N95 H123 H124 S149 S156 A157 A158 Q185 V188 V190 I193 K317 E321 R325
Annotation score	1

Enzyme Commision number

	Molecular Function
GO:0001786	phosphatidylserine binding
GO:0005548	phospholipid transporter activity
GO:0008289	lipid binding
GO:0010314	phosphatidylinositol-5-phosphate binding
GO:0032934	sterol binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
GO:0070273	phosphatidylinositol-4-phosphate binding
GO:0070300	phosphatidic acid binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding
GO:0120015	sterol transfer activity

	Biological Process
GO:0006869	lipid transport
GO:0006887	exocytosis
GO:0006897	endocytosis
GO:0015914	phospholipid transport
GO:0015918	sterol transport
GO:0016125	sterol metabolic process
GO:0030011	maintenance of cell polarity
GO:0034727	piecemeal microautophagy of the nucleus
GO:0055092	sterol homeostasis

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032541	cortical endoplasmic reticulum

PDB	RCSB:4ph7, PDBe:4ph7, PDBj:4ph7
PDBsum	4ph7
PubMed	26206936
UniProt	Q02201\|OSH6_YEAST Oxysterol-binding protein homolog 6 (Gene Name=OSH6)

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Structure of PDB 4ph7 Chain A Binding Site BS01