Structure of PDB 4p7i Chain A Binding Site BS01

Receptor Information
>4p7i Chain A (length=294) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI
KDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLF
FLQVKKQILDEKVYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL
LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYG
VNYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD
KEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4p7i Structural basis of the binding of Merlin FERM domain to the E3 ubiquitin ligase substrate adaptor DCAF1.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		I261 R262 N263 I264 S265 Y266 I301 H304 M308 R309 K312
Binding residue
(residue number reindexed from 1)		I243 R244 N245 I246 S247 Y248 I283 H286 M290 R291 K294
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0008092 cytoskeletal protein binding
Cellular Component
GO:0005856 cytoskeleton

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:4p7i, PDBe:4p7i, PDBj:4p7i
PDBsum4p7i
PubMed24706749
UniProtP46662|MERL_MOUSE Merlin (Gene Name=Nf2)

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