Structure of PDB 4p4o Chain A Binding Site BS01

Receptor Information
>4p4o Chain A (length=306) Species: 5671 (Leishmania infantum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QEMADLNNALGEKYKVSSYHKLLKKATKPKLKAIQELTQVHGFGPRAAAA
LFDREGIFTVDELLQKADSIPSLTDQQRVGIKYFYDINEKIPMQESVLHE
NYLREKCMEVLGKDFSILICGSYRRRHPFSGDVDAILSRTLDAPPLSEPV
AATGVLGHFVEFLESLKYLEATMAQGPLKYMGMGRLPPRINTKVYKARRV
DIRLIETKSVPTAMLTFTGSKNFNVIMRQAAISKGYLLNEYGLFKLGTPE
EARALYERIGIRGKNAGEELGVPKDELEDKRVEVRSEQDVFDVLGMPYAK
PENRDP
Ligand information
Receptor-Ligand Complex Structure
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PDB4p4o Structures of the Leishmania infantum polymerase beta.
Resolution2.3001 Å
Binding residue
(original residue number in PDB)		H103 G104 F105 G106 R108 A109 K241 M243 R269 D271
Binding residue
(residue number reindexed from 1)		H41 G42 F43 G44 R46 A47 K179 M181 R199 D201
Enzymatic activity
Catalytic site (original residue number in PDB) D271
Catalytic site (residue number reindexed from 1) D201
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0034061 DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4p4o, PDBe:4p4o, PDBj:4p4o
PDBsum4p4o
PubMed24666693
UniProtQ9U6N3

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