Structure of PDB 4p0p Chain A Binding Site BS01

Receptor Information
>4p0p Chain A (length=283) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QQQPLELRPGEYRVLLCVDIGETRGPELLRELQRLHVTHTVRKLHVGDFV
WVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRC
GLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESA
AYLALLTRGLQRLYQGHTLRSRPWGTPGPNPLCSLLTFSDFNAGAIKNKA
QSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQET
LLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT
Ligand information
Receptor-Ligand Complex Structure
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PDB4p0p Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		I344 T383 Q386 A387 R530 N531
Binding residue
(residue number reindexed from 1)		I85 T124 Q127 A128 R262 N263
Enzymatic activity
Enzyme Commision number 3.1.22.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0008821 crossover junction DNA endonuclease activity
Biological Process
GO:0006302 double-strand break repair
GO:0006308 DNA catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4p0p, PDBe:4p0p, PDBj:4p0p
PDBsum4p0p
PubMed24733841
UniProtQ96NY9|MUS81_HUMAN Crossover junction endonuclease MUS81 (Gene Name=MUS81)

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