Structure of PDB 4oyf Chain A Binding Site BS01

Receptor Information
>4oyf Chain A (length=399) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLV
MPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFN
PGAGIHLAVGGQLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITY
LMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVM
AEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKD
AMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALY
QGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL
HSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain4oyf Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4oyf Coupled ion binding and structural transitions along the transport cycle of glutamate transporters.
Resolution3.41 Å
Binding residue
(original residue number in PDB)		S278 G306 A307 N310 N401 D405
Binding residue
(residue number reindexed from 1)		S261 G289 A290 N293 N384 D388
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005283 amino acid:sodium symporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015501 glutamate:sodium symporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0035725 sodium ion transmembrane transport
GO:0046942 carboxylic acid transport
GO:0070207 protein homotrimerization
GO:0070778 L-aspartate transmembrane transport
GO:0140009 L-aspartate import across plasma membrane
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4oyf, PDBe:4oyf, PDBj:4oyf
PDBsum4oyf
PubMed24842876
UniProtO59010|GLT_PYRHO Glutamate transporter homolog (Gene Name=PH1295)

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