Structure of PDB 4oxb Chain A Binding Site BS01

Receptor Information
>4oxb Chain A (length=133) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPPQFTRAQWFAIQHISLNPPRCTIAMRAINNYRWRCKNQNTFLRTTFAN
VVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNISNCRYAD
RPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain4oxb Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4oxb The sulfate-binding site structure of the human eosinophil cationic protein as revealed by a new crystal form.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		R34 N39
Binding residue
(residue number reindexed from 1)		R34 N39
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) K38 H128 L129 D130
Catalytic site (residue number reindexed from 1) K38 H128 L129 D130
Enzyme Commision number 3.1.27.-
Gene Ontology
Molecular Function
GO:0001530 lipopolysaccharide binding
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0004540 RNA nuclease activity
Biological Process
GO:0002227 innate immune response in mucosa
GO:0006401 RNA catabolic process
GO:0006935 chemotaxis
GO:0019731 antibacterial humoral response
GO:0042742 defense response to bacterium
GO:0043152 induction of bacterial agglutination
GO:0045087 innate immune response
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0035578 azurophil granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4oxb, PDBe:4oxb, PDBj:4oxb
PDBsum4oxb
PubMed
UniProtP12724|ECP_HUMAN Eosinophil cationic protein (Gene Name=RNASE3)

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