Structure of PDB 4ouc Chain A Binding Site BS01

Receptor Information
>4ouc Chain A (length=329) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPD
LVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSY
PPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKL
SSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTL
NGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQF
DIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQ
IKRKIQEFHRTMLNFSSATDLLCQHSLFK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ouc Modulation of the chromatin phosphoproteome by the haspin protein kinase.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		G493 V494 N588 E613 D649 D707 D709 G713 D714 Q718 F719 Y722
Binding residue
(residue number reindexed from 1)		G24 V25 N119 E144 D180 D238 D240 G244 D245 Q249 F250 Y253
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ouc, PDBe:4ouc, PDBj:4ouc
PDBsum4ouc
PubMed24732914
UniProtQ8TF76|HASP_HUMAN Serine/threonine-protein kinase haspin (Gene Name=HASPIN)

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