Structure of PDB 4os5 Chain A Binding Site BS01
Receptor Information
>4os5 Chain A (length=245) Species:
9606
(Homo sapiens) [
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IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIAL
LKIRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLY
PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHT
Ligand information
>4os5 Chain B (length=14) [
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GLALGRGCENHRCL
Receptor-Ligand Complex Structure
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PDB
4os5
Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Resolution
2.26 Å
Binding residue
(original residue number in PDB)
R35 V41 H57 C58 D60A Y60B H99 D189 S190 C191 Q192 G193 S195 W215 G218 G226
Binding residue
(residue number reindexed from 1)
R20 V30 H46 C47 D50 Y51 H94 D192 S193 C194 Q195 G196 S198 W218 G221 G229
Enzymatic activity
Catalytic site (original residue number in PDB)
H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1)
H46 D97 Q195 G196 D197 S198 G199
Enzyme Commision number
3.4.21.73
: u-plasminogen activator.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
Biological Process
GO:0006508
proteolysis
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Molecular Function
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Biological Process
External links
PDB
RCSB:4os5
,
PDBe:4os5
,
PDBj:4os5
PDBsum
4os5
PubMed
25343607
UniProt
P00749
|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)
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