Structure of PDB 4ojv Chain A Binding Site BS01

Receptor Information
>4ojv Chain A (length=363) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVVFEITILGANGGPTEYGTQCFILKPARTEDPELIAVDGGAGMYQLREM
LVQGDDELVPSFYEHDREPIEFFIDSKLNIQKGLSKSLLQSLKRQGEHFE
SANTMKKTYEVFQGITDYYITHPHLDHISGLVVNSPSIYEQENSKKKTIW
GLPHTIDVLQKHVFNDLIWPDLTAERSRKLKLKCLNPKEVQKCTIFPWDV
IPFKVHHGIGVKTGAPVYSTFYIFRDRKSKDCIIVCGDVEQDRRESEESL
LEEFWSYVAENIPLVHLKGILVECSCPLSSKPEQLYGHLSPIYLINELSN
LNTLYNSSKGLSGLNVIVTHVKSTPAKRDPRLTILEELRFLAEERNLGDL
RISIALEGHTLFL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4ojv Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ojv Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate.
Resolution1.31 Å
Binding residue
(original residue number in PDB)		H128 H130 H213 D244
Binding residue
(residue number reindexed from 1)		H122 H124 H207 D238
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004118 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0004119 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0006198 cAMP catabolic process
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:1902660 negative regulation of glucose mediated signaling pathway
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ojv, PDBe:4ojv, PDBj:4ojv
PDBsum4ojv
PubMed25050706
UniProtP22434|PDE1_YEAST 3',5'-cyclic-nucleotide phosphodiesterase 1 (Gene Name=PDE1)

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