Structure of PDB 4oi4 Chain A Binding Site BS01

Receptor Information
>4oi4 Chain A (length=428) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGDNEWHKLVIPKGSDWQIDLKAEGKLIVKVNSGIVEIFGTELAVDDEYT
FQNWKFPIYAVEETELLWKCPDLTTNTITVKPNHTMKYIYNLHFMLEKIR
MSNFEGPRVVIVGGSQTGKTSLSRTLCSYALKFNAYQPLYINLDPQQPIF
TVPGCISATPISDILDAQLPTWGQSLTSGATLLHNKQPMVKNFGLERINE
NKDLYLECISQLGQVVGQRLHLDPQVRRSGCIVDTPSISQLDENLAELHH
IIEKLNVNIMLVLCSETDPLWEKVKKTFGPELGNNNIFFIPKLDGVSAVD
DVYKRSLQRTSIREYFYGSLDTALSPYAIGVDYEDLTIWKPSNVFDNEVG
RVELFPVTITPSNLQHAIIAITFAERRADQATVIKSPILGFALITEVNEK
RRKLRVLLPVPGRLPSKAMILTSYRYLE
Ligand information
>4oi4 Chain B (length=25) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KNIQSRNWYLSDSQWAAFKDDEITS
Receptor-Ligand Complex Structure
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PDB4oi4 RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase clp1.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		T168 S179 Q191 S192 L193 T194 S195 G196 A197 H201 N202 Q204 P205 M206 V232 Q235 R236 L239 Q242 Y332 L341 S342 F390 L406 P426 V427 P428
Binding residue
(residue number reindexed from 1)		T151 S162 Q174 S175 L176 T177 S178 G179 A180 H184 N185 Q187 P188 M189 V215 Q218 R219 L222 Q225 Y315 L324 S325 F373 L389 P409 V410 P411
Enzymatic activity
Enzyme Commision number 2.7.1.78: polynucleotide 5'-hydroxyl-kinase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051731 polynucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0031124 mRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005849 mRNA cleavage factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4oi4, PDBe:4oi4, PDBj:4oi4
PDBsum4oi4
PubMed24813946
UniProtQ08685|CLP1_YEAST mRNA cleavage and polyadenylation factor CLP1 (Gene Name=CLP1)

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