Structure of PDB 4oh4 Chain A Binding Site BS01

Receptor Information

>4oh4 Chain A (length=303) Species: 3702 (Arabidopsis thaliana)

DLEVLFQGPHMAFEKPLRKLTFADLLQATNGFHNDSLIGSGGFGDVYKAI
LKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDE
RLLVYEFMKYGSLEDVLHDKLNWSTRRKIAIGSARGLAFLHHNCSPHIIH
RDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY
YQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLR
ISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKE
IQA

Ligand information

>4oh4 Chain E (length=16) Species: 3702 (Arabidopsis thaliana)

TMEELQAAIQAAIAHC

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4oh4 Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1.
• Resolution: 2.25 Å
• Binding residue (original residue number in PDB): K1101 I1108 L1128 K1132 V1135
• Binding residue (residue number reindexed from 1): K244 I251 L271 K275 V278

Enzymatic activity

• Catalytic site (original residue number in PDB): D1009 K1011 S1013 N1014 D1027 M1037 T1049
• Catalytic site (residue number reindexed from 1): D152 K154 S156 N157 D170 M180 T192
• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.
  2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:4oh4, PDBe:4oh4, PDBj:4oh4
• PDBsum: 4oh4
• PubMed: 25331450
• UniProt: O22476|BRI1_ARATH Protein BRASSINOSTEROID INSENSITIVE 1 (Gene Name=BRI1)