Structure of PDB 4oc7 Chain A Binding Site BS01

Receptor Information
>4oc7 Chain A (length=213) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DMPVERILEAELAVEPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD
DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAI
FDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREK
VYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDT
PIDTFLMEMLEAP
Ligand information
Receptor-Ligand Complex Structure
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PDB4oc7 A natural-product switch for a dynamic protein interface.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		F277 V280 K284 L294 V298 F450 E453
Binding residue
(residue number reindexed from 1)		F32 V35 K39 L49 V53 F205 E208
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4oc7, PDBe:4oc7, PDBj:4oc7
PDBsum4oc7
PubMed24821627
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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