Structure of PDB 4obh Chain A Binding Site BS01
Receptor Information
>4obh Chain A (length=99) Species:
11685
(HIV-1 M:B_ARV2/SF2) [
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PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPGKWKPKMIGGI
GGFIKVRQYDQIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Ligand information
>4obh Chain E (length=10) Species:
11676
(Human immunodeficiency virus 1) [
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RPGNFFQSRP
Receptor-Ligand Complex Structure
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PDB
4obh
HIV-1 protease-substrate coevolution in nelfinavir resistance.
Resolution
1.85 Å
Binding residue
(original residue number in PDB)
R8 N25 G27 A28 D29 D30 M46 I47 G48 P81
Binding residue
(residue number reindexed from 1)
R8 N25 G27 A28 D29 D30 M46 I47 G48 P81
Enzymatic activity
Catalytic site (original residue number in PDB)
N25 T26 G27
Catalytic site (residue number reindexed from 1)
N25 T26 G27
Enzyme Commision number
2.7.7.-
2.7.7.49
: RNA-directed DNA polymerase.
2.7.7.7
: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2
: exoribonuclease H.
3.1.26.13
: retroviral ribonuclease H.
3.4.23.16
: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0004190
aspartic-type endopeptidase activity
Biological Process
GO:0006508
proteolysis
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Molecular Function
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Biological Process
External links
PDB
RCSB:4obh
,
PDBe:4obh
,
PDBj:4obh
PDBsum
4obh
PubMed
24719428
UniProt
P03369
|POL_HV1A2 Gag-Pol polyprotein (Gene Name=gag-pol)
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