Structure of PDB 4o9w Chain A Binding Site BS01
Receptor Information
>4o9w Chain A (length=211) Species:
9606
(Homo sapiens) [
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HLSDMLQQLHSVNASKPSELVRQEEAEDPACIPIFWVSKWVDYSDKYGLG
YQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMK
KITLLKYFRNYMSEHLLKAGANITLPYLRTWFRTRSAIILHLSNGSVQIN
FFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYA
RTMVDKLLSSR
Ligand information
>4o9w Chain B (length=5) Species:
9606
(Homo sapiens) [
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VLSTL
Receptor-Ligand Complex Structure
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PDB
4o9w
The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores.
Resolution
1.694 Å
Binding residue
(original residue number in PDB)
W414 D416 Y485 L490 L491 H538 K540
Binding residue
(residue number reindexed from 1)
W40 D42 Y111 L116 L117 H155 K157
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:4o9w
,
PDBe:4o9w
,
PDBj:4o9w
PDBsum
4o9w
PubMed
25109385
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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