Structure of PDB 4o6a Chain A Binding Site BS01

Receptor Information
>4o6a Chain A (length=361) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQL
NTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRG
NPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVT
LLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPF
YLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRK
ECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNL
SSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEY
ERNNGFPIFDK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4o6a The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Resolution1.859 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 K184 H203 E386 K395
Binding residue
(residue number reindexed from 1)
R13 L14 K15 R16 K39 H58 E241 K250
Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
External links
PDB RCSB:4o6a, PDBe:4o6a, PDBj:4o6a
PDBsum4o6a
PubMed24462292
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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