Structure of PDB 4o5v Chain A Binding Site BS01

Receptor Information

>4o5v Chain A (length=213) Species: 273075 (Thermoplasma acidophilum DSM 1728) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

IRSVTEEDYLKIIQELVLYKGYATLADISRSLNVKRQSVRDEINHLISLS
MAEKIERGKYRLTPSGDREANRFLRKHRTAEILLSRCIGIPWERVDEEAM
GIEHGMTEEIIQRTIERFGVDRCPHGNPIPDPEGNVEPVADVRITSLLPD
STARISRIVYETDDILHFLALNGLIPGKDIKIESVKDTVRVLVDGRSIEI
PTDIAMAIMVTVD

Ligand information

InChI=1S/Fe/q+2

CWYNVVGOOAEACU-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Fe+2]
CACTVS 3.341	[Fe++]

Formula

Name

FE (II) ION

PDB chain

4o5v Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4o5v Structural analysis and insight into metal-ion activation of the iron-dependent regulator from Thermoplasma acidophilum.
Resolution	2.1 Å
Binding residue (original residue number in PDB)	E86 C128 H130 E166
Binding residue (residue number reindexed from 1)	E81 C123 H125 E161
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	R73 I95 P96 R99
Catalytic site (residue number reindexed from 1)	R68 I90 P91 R94
Enzyme Commision number	?

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0046872	metal ion binding
GO:0046914	transition metal ion binding
GO:0046983	protein dimerization activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:4o5v, PDBe:4o5v, PDBj:4o5v
PDBsum	4o5v
PubMed	24816097
UniProt	Q9HJU1

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