Structure of PDB 4o56 Chain A Binding Site BS01
Receptor Information
>4o56 Chain A (length=244) Species:
9606
(Homo sapiens) [
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LGSPGIQGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIF
WVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGT
ESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLP
YLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDF
RTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
Ligand information
>4o56 Chain B (length=8) [
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GPMTSTPK
Receptor-Ligand Complex Structure
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PDB
4o56
Integration of Charge-dipole Interaction and Intramolecular Hydrogen Bond in Ligand Design for the Polo-Box Domain of Polo-like Kinase 1
Resolution
1.8 Å
Binding residue
(original residue number in PDB)
K413 W414 D416 S487 H489 L490 L491 R516 F535 H538 K540
Binding residue
(residue number reindexed from 1)
K54 W55 D57 S128 H130 L131 L132 R157 F176 H179 K181
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:4o56
,
PDBe:4o56
,
PDBj:4o56
PDBsum
4o56
PubMed
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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