Structure of PDB 4o42 Chain A Binding Site BS01

Receptor Information
>4o42 Chain A (length=173) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFETIERFMDCRIGRKGATGATTTIYAVEADGDPNAGFEKNKEPGEIQYL
IKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETKRWLKNASPE
DVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYS
ECSWEDGALISKKFQACIDEYFS
Ligand information
>4o42 Chain B (length=7) Species: 387159 (Influenza A virus (A/Hong Kong/5/1983(H3N2))) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
RTARSKV
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4o42 Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Resolution1.87 Å
Binding residue
(original residue number in PDB)		E272 A290 Y295 W322 G324 W325 H329 D408 E424 D425
Binding residue
(residue number reindexed from 1)		E3 A21 Y26 W53 G55 W56 H60 D139 E155 D156
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
External links
PDB RCSB:4o42, PDBe:4o42, PDBj:4o42
PDBsum4o42
PubMed24853335
UniProtO14646|CHD1_HUMAN Chromodomain-helicase-DNA-binding protein 1 (Gene Name=CHD1)

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