Structure of PDB 4o3q Chain A Binding Site BS01

Receptor Information
>4o3q Chain A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRA
AIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPI
RKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMC
RGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERL
TKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTV
IKNCNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB4o3q Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta
Resolution1.72 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 R61 S62 W64 K86 L89 R93 K293 R313 P316 K317 T318 I319 G320 C321 S322 K323 N324 P326 G327 L378 F423
Binding residue
(residue number reindexed from 1)		Q41 Y42 W45 R64 S65 W67 K89 L92 R96 K291 R311 P314 K315 T316 I317 G318 C319 S320 K321 N322 P324 G325 L376 F421
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4o3q, PDBe:4o3q, PDBj:4o3q
PDBsum4o3q
PubMed24759104
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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