Structure of PDB 4nyz Chain A Binding Site BS01

Receptor Information
>4nyz Chain A (length=460) Species: 12107 (Mengo virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GALERLPDGPRIHVPRKTALRPTVARQVFQPAFAPAVLSKFDPRTDADVD
EVAFSKHTSNQETLPPVFRMVAREYANRVFALLGRDNGRLSVKQALDGLE
GMDPMDKNTSPGLPYTTLGMRRTDVVDWETATLIPFAAERLEKMNNKDFS
DIVYQTFLKDELRPIEKVQAAKTRIVDVPPFEHCILGRQLLGKFASKFQT
QPGLELGSAIGCDPDVHWTAFGVAMQGFERVYDVDYSNFDSTHSVAVFRL
LAEEFFSEENGFDPLVKDYLESLAISKHAYEEKRYLITGGLPSGCAATSM
LNTIMNNIIIRAGLYLTYKNFEFDDVKVLSYGDDLLVATNYQLNFDRVRT
SLAKTGYKITPANKTSTFPLESTLEDVVFLKRKFKKEGPLYRPVMNREAL
EAMLSYYRPGTLSEKLTSITMLAVHSGKQEYDRLFAPFREVGVIVPTFES
VEYRWRSLFW
Ligand information
Ligand IDGLN
InChIInChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
InChIKeyZDXPYRJPNDTMRX-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(=O)N)C(C(=O)O)N
OpenEye OEToolkits 1.5.0C(CC(=O)N)[C@@H](C(=O)O)N
ACDLabs 10.04O=C(N)CCC(N)C(=O)O
CACTVS 3.341N[CH](CCC(N)=O)C(O)=O
CACTVS 3.341N[C@@H](CCC(N)=O)C(O)=O
FormulaC5 H10 N2 O3
NameGLUTAMINE
ChEMBLCHEMBL930
DrugBankDB00130
ZINCZINC000001532526
PDB chain4nyz Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4nyz The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site
Resolution2.15 Å
Binding residue
(original residue number in PDB)		N238 S241 T242 H243 G290 L291 D333
Binding residue
(residue number reindexed from 1)		N238 S241 T242 H243 G290 L291 D333
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4nyz, PDBe:4nyz, PDBj:4nyz
PDBsum4nyz
PubMed24600002
UniProtP12296|POLG_ENMGO Genome polyprotein

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