Structure of PDB 4ny3 Chain A Binding Site BS01

Receptor Information
>4ny3 Chain A (length=299) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVS
EAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVA
TVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGV
LRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGGVWGLDDFQFLPFIWG
SSQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKTGPFAEHSN
QLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ny3 Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.
Resolution1.797 Å
Binding residue
(original residue number in PDB)		I278 K286 G290 R293 M294 A297 E298
Binding residue
(residue number reindexed from 1)		I255 K263 G267 R270 M271 A274 E275
Enzymatic activity
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Gene Ontology
Molecular Function
GO:0019211 phosphatase activator activity

View graph for
Molecular Function
External links
PDB RCSB:4ny3, PDBe:4ny3, PDBj:4ny3
PDBsum4ny3
PubMed25003389
UniProtQ15257|PTPA_HUMAN Serine/threonine-protein phosphatase 2A activator (Gene Name=PTPA)

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